| ncRNA name | DLL4 shRNA |
| ncRNA Category | shRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line WERI-RB1 and Y79 |
| Methods | shRNA knockdown, qPCR, immunohistochemistry, CCK-8 assay, Ki67 incorporation assay, immunofluorescence, transwell assay, microarray |
| Expression pattern | associated |
| Functional description | Notch pathway is active in WERI-RB1 and Y79, and in most human retinoblastoma samples. Inhibition of the pathway by downregulating Jag2, DLL4 or CBF1 using short hairpin RNA, potently reduced growth, proliferation and clonogenicity in both lines. |
| PubMed ID | 27661116 |
| Year | 2016 |
| Title | Targeting Notch signaling as a novel therapy for retinoblastoma. |
| Drug-related ncRNA | NA |
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